BRCA1, BRCA2 and primary ovarian insufficiency
نویسندگان
چکیده
منابع مشابه
Primary Ovarian Insufficiency
Primary ovarian insufficiency or premature menopause is one of the stressful problems in women younger than 40, which may cause numerous early or late psychological and physical complications. Failure of germ cell development is associated with complete ovarian insufficiency, while their decreased number is more likely associated with partial ovarian insufficiency, which leads to secondary amen...
متن کاملInactivation of BRCA1 and BRCA2 in ovarian cancer.
BACKGROUND Although BRCA1 and BRCA2 play important roles in hereditary ovarian cancers, the extent of their role in sporadic ovarian cancers and their mechanisms of inactivation are not yet well understood. Our goal was to characterize BRCA2 mutations and mRNA expression in a group of ovarian tumors previously evaluated for BRCA1 mutations and mRNA expression. METHODS The tumors of 92 unrelat...
متن کاملPathology of ovarian cancers in BRCA1 and BRCA2 carriers.
PURPOSE Germline mutations in the BRCA1 and BRCA2 genes confer increased susceptibility to ovarian cancer. There is evidence that tumors in carriers may exhibit a distinct distribution of pathological features, but previous studies on the pathology of such tumors have been small. Our aim was to evaluate the morphologies and immunophenotypes in a large cohort of patients with familial ovarian ca...
متن کاملPrimary Ovarian Insufficiency
From the Integrative Reproductive Medi cine Unit, Intramural Research Program on Reproductive and Adult Endocrinology, National Institute of Child Health and Hu man Development, National Institutes of Health, Bethesda, MD. Address reprint requests to Dr. Nelson at the Integrative Reproductive Medicine Unit, NICHD– Intramural Research Program on Repro ductive and Adult Endocrinology, CRC, Rm....
متن کاملBRCA1 and BRCA2
But isn't inherited breast cancer quite rare? Well of course most breast cancers aren’t hereditary. Inherited predisposition accounts for about 5% of all breast cancers — mutations in BRCA1 and BRCA2 probably cause a significant proportion of these. So BRCA mutation doesn’t cause a high fraction of all breast cancers, but, because this disease is so common (about 1 in 10 lifetime risk), it adds...
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ژورنال
عنوان ژورنال: E3S Web of Conferences
سال: 2020
ISSN: 2267-1242
DOI: 10.1051/e3sconf/202016505009